BIC373 - Biochemistry

Subject Title
Biochemistry

Subject Description
This course extends the student's knowledge regarding theory and techniques applied in the field of biotechnology by exploring the biochemical reactions that govern life and laboratory-based conclusions. Students will recognize how the molecular environment surrounding biological macromolecules dictates organization and interactions while considering the implications of thermodynamics to the control. Successfully conceptualizing the molecular basis of the interactions that occur between functional groups of various macromolecules in aqueous environments and how these interactions affect functional outcomes in living systems or biotechniques is a critical milestone in a biotechnologist's learning.

Emphasis will be placed on the structure, function and metabolism of amino acids, proteins and DNA and how these molecules produce the work required for the lifecycle of a cell. Production of nucleic acids and lipids from metabolic activities, genetic control, energy transfer, membrane dynamics and cell signaling cascades including primary, secondary and lipid messengers involved in metabolism and regulation of gene expression will be discussed with regards to the synthesis of functional proteins.

Throughout the course, the association of academic and Industrial professional environments will be discussed. The molecular mechanisms underlying various laboratory techniques currently used to investigate amino acids, protein, nucleic acids, and lipids will be presented. For example, the application of phase separations will be explored through current macromolecular research initiatives in biotechnology.

Credit Status
1 credit towards the BTA diploma

Learning Outcomes
Upon successful completion of this subject the student will be able to:

1. Relate the chemistry of various functional groups to the structure and function of biological macromolecules found in aqueous solutions
2. Explain the effects on macromolecular structure and function resulting from exposure to varying parameters including heat, salt, pH, and reducing agents resulting from cellular processing and experimental manipulations.
3. Identify how the thermodynamics of a system affects the spontaneity of biological reactions.
4. Conceptualize key steps in the production of functional proteins from monomers including various control mechanisms utilized in cellular and laboratory environments.
5. Relate the coordinated and successive actions of various macromolecules found in molecular networks to the functional outcomes of metabolism and gene expression including inhibition at various points.
6. Interpret presented and prepared graphical interpretations of enzyme assays to compare total and specific enzyme activity.
7. Categorize various methods for the separation and detection of biotechnologically relevant molecules utilized in biotechnological applications.
8. Forecast changes in polymer structure resulting from changes in primary sequence in biological macromolecules relevant to biotechnological applications.

Essential Employability Skills

    •  Communicate clearly, concisely and correctly in the written, spoken and visual form that fulfils the purpose and meets the needs of the audience.

    •  Respond to written, spoken, or visual messages in a manner that ensures effective communication.

    •  Apply a systematic approach to solve problems.

    •  Use a variety of thinking skills to anticipate and solve problems.

    •  Locate, select, organize, and document information using appropriate technology and information systems.

    •  Analyze, evaluate, and apply relevant information from a variety of sources.

    •  Interact with others in groups or teams in ways that contribute to effective working relationships and the achievement of goals.

    •  Manage the use of time and other resources to complete projects.

    •  Take responsibility for one's own actions, decisions, and consequences.

Academic Integrity
Seneca upholds a learning community that values academic integrity, honesty, fairness, trust, respect, responsibility and courage. These values enhance Seneca's commitment to deliver high-quality education and teaching excellence, while supporting a positive learning environment. Ensure that you are aware of Seneca's Academic Integrity Policy which can be found at: http://www.senecapolytechnic.ca/about/policies/academic-integrity-policy.html Review section 2 of the policy for details regarding approaches to supporting integrity. Section 2.3 and Appendix B of the policy describe various sanctions that can be applied, if there is suspected academic misconduct (e.g., contract cheating, cheating, falsification, impersonation or plagiarism).

Please visit the Academic Integrity website http://open2.senecac.on.ca/sites/academic-integrity/for-students to understand and learn more about how to prepare and submit work so that it supports academic integrity, and to avoid academic misconduct.

Discrimination/Harassment
All students and employees have the right to study and work in an environment that is free from discrimination and/or harassment. Language or activities that defeat this objective violate the College Policy on Discrimination/Harassment and shall not be tolerated. Information and assistance are available from the Student Conduct Office at student.conduct@senecapolytechnic.ca.

Accommodation for Students with Disabilities
The College will provide reasonable accommodation to students with disabilities in order to promote academic success. If you require accommodation, contact the Counselling and Accessibility Services Office at ext. 22900 to initiate the process for documenting, assessing and implementing your individual accommodation needs.

Camera Use and Recordings - Synchronous (Live) Classes
Synchronous (live) classes may be delivered in person, in a Flexible Learning space, or online through a Seneca web conferencing platform such as MS Teams or Zoom. Flexible Learning spaces are equipped with cameras, microphones, monitors and speakers that capture and stream instructor and student interactions, providing an in-person experience for students choosing to study online.

Students joining a live class online may be required to have a working camera in order to participate, or for certain activities (e.g. group work, assessments), and high-speed broadband access (e.g. Cable, DSL) is highly recommended. In the event students encounter circumstances that impact their ability to join the platform with their camera on, they should reach out to the professor to discuss. Live classes may be recorded and made available to students to support access to course content and promote student learning and success.

By attending live classes, students are consenting to the collection and use of their personal information for the purposes of administering the class and associated coursework. To learn more about Seneca's privacy practices, visit Privacy Notice.