PAC633 - Organic Chemistry

Outline information
Semester
Schools offering this subject
Last revision date 2016-12-01 10:13:17.929
Last review date 2016-12-01 10:13:40.33

Subject Title
Organic Chemistry

Subject Description

The lecture section of this Subject includes:

  • The structural and pharmaceutical properties of amines.
  • Theory and practical aspects of mass spectroscopy. . These sets of lectures are intended to include pre-laboratory lecture topics to carry out the data acquisition and data analysis of the qualitative analysis of an unknown mixture by  gas  chromatography coupled with mass spectrometer detector
  • A brief look at the principles of liquid chromatography coupled with electron spray ionization mass spectrometry form part II of the mass spectroscopy theory .
  • The physico-chemical properties that influence the reactivity of drug molecules and correlation of structure and activity.
  • An introduction to the principles of combinatorial synthesis [if time permits or as a self study section].

A portion of the lecture periods will also  be used to explain the theory and procedure details behind the laboratory projects.

Laboratory section of this Subject deals with:
  • A multi-step synthesis of an anaesthetic (lidocaine)
  • The assay of this product by HPLC method.
  • Qualitative mass-spectrometric analysis of an unknown organic compound (or mixture) .
  • Quantitative mass-spectrometric analysis by SIM mode [ if time permits]

Credit Status
If applicable the subject is worth one credit towards a diploma in the Pharmaceutical Technology program.

Pre-requisites
CHO 433

Learning Outcomes
Upon successful completion of this subject the student will be able to:

  • Carry out a nucleophilic acylation reaction.
  • Explain the reactivity of the different acid derivatives in acylation reactions to judge the outcome of such acylations.
  • Describe the need for and know how to remove HCl while carrying out acylation reactions of amines.
  • Explain the relative reactivity of amines and amides as nucleophilic agents.
  • Explain the basis of recovering a basic compound in synthetic organic chemistry.
  • Be able to calculate the % loss of a product in isolation based on the yield of an easily recoverable byproduct.
  • Be able to calculate the overall yield in a multi step synthesis and the yield for each step.
  • Explain the basic instrumentation in a mass spectrometer coupled with a gas chromatographic system.
  • Explain the basic theory of an electron ionization mass spectrometer and detection by a quadrupole mass analyzer.
  • Be able to do a qualitative analysis of an organic mixture in a mass spectrometer coupled with a gas chromatographic system.
  • Explain the meaning of SCAN and SIM modes in mass spectral analysis.
  • Explain the meaning of a total ion chromatogram in mass spectral analysis.
  • Be able to generate a total ion chromatogram from mass spectral data.
  • Be able to do qualitative identification by library search in mass spectral analysis.
  • Explain the meaning of and the use of an extracted ion chromatogram in mass spectral analysis.
  • Be able to generate an extracted ion chromatogram in mass spectral analysis.
  • Be able to check the validity of a library identification by isotopic abundance ratio.
  • Be able to Explain the basic principles of an electron spray ionization mass spectrometry.
  • Be able to do an HPLC assay of a raw material using USP protocol.
  • Be able to use Chemstation software to do an internal standard assay.
  • Explain the meaning and significance of physico-chemical properties that affect - drug-receptor interactions and therefore drug design.
  • Be able to Explain the principle behind combinatorial synthesis

These learning outcomes will be modified to include additional points if other relevant topics could be covered in the lecture segment after the discussion of the above.

Essential Employability Skills
Communicate clearly, concisely and correctly in the written, spoken and visual form that fulfils the purpose and meets the needs of the audience.

Respond to written, spoken, or visual messages in a manner that ensures effective communication.

Execute mathematical operations accurately.

Apply a systematic approach to solve problems.

Use a variety of thinking skills to anticipate and solve problems.

Locate, select, organize, and document information using appropriate technology and information systems.

Analyze, evaluate, and apply relevant information from a variety of sources.

Cheating and Plagiarism
Each student should be aware of the College's policy regarding Cheating and Plagiarism. Seneca's Academic Policy will be strictly enforced.

To support academic honesty at Seneca College, all work submitted by students may be reviewed for authenticity and originality, utilizing software tools and third party services. Please visit the Academic Honesty site on http://library.senecacollege.ca for further information regarding cheating and plagiarism policies and procedures.

Discrimination/Harassment
All students and employees have the right to study and work in an environment that is free from discrimination and/or harassment. Language or activities that defeat this objective violate the College Policy on Discrimination/Harassment and shall not be tolerated. Information and assistance are available from the Student Conduct Office at student.conduct@senecacollege.ca.

Accommodation for Students with Disabilities
The College will provide reasonable accommodation to students with disabilities in order to promote academic success. If you require accommodation, contact the Counselling and Disabilities Services Office at ext. 22900 to initiate the process for documenting, assessing and implementing your individual accommodation needs.